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Article

Distinct modes of ATR activation after replication stress and DNA double-strand breaks in Caenorhabditis elegans.

The EMBO journal - 21 Dec 2005

Garcia-Muse Tatiana, Boulton Simon J

Abstract excerpt

ATM and ATR are key components of the DNA damage checkpoint. ATR primarily responds to UV damage and replication stress, yet may also function with ATM in the checkpoint response to DNA double-strand breaks (DSBs), although this is less clear. Here, we show that atl-1 (Caenorhabditis elegans ATR) and rad-5/clk-2 prevent mitotic catastrophe, function in the S-phase checkpoint and also cooperate with atm-1 in the...

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Source

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Identifiers

PMID: 16319925
DOI: 10.1038/sj.emboj.7600896
PMCID: PMC1356337

Genes

ATR
ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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