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Article

Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation.

Molecular and cellular biology - 1 Aug 2006

Liu Shizhou, Bekker-Jensen Simon, Mailand Niels, Lukas Claudia, Bartek Jiri, Lukas Jiri

Abstract excerpt

TopBP1 and Claspin are adaptor proteins that facilitate phosphorylation of Chk1 by the ATR kinase in response to genotoxic stress. Despite their established requirement for Chk1 activation, the exact way in which TopBP1 and Claspin control Chk1 phosphorylation remains unclear. We show that TopBP1 tightly colocalizes with ATR in distinct nuclear subcompartments generated by DNA damage. Although depletion of TopBP1...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 16880517
DOI: 10.1128/MCB.00492-06
PMCID: PMC1592810

Genes

ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation.PMID 16880517Read ↗

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Structural basis for recruitment of the CHK1 DNA damage kinase by the CLASPIN scaffold protein.Semantic proximity Read ↗

The Rad9A checkpoint protein is required for nuclear localization of the claspin adaptor protein.Semantic proximity Read ↗

HCLK2 Is Required for Activity of the DNA Damage Response Kinase ATRSemantic proximity Read ↗

SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response.Semantic proximity Read ↗

Overexpression of TopBP1, a canonical ATR/Chk1 activator, paradoxically hinders ATR/Chk1 activation in cancerSemantic proximity Read ↗

Reconstitution of human claspin-mediated phosphorylation of Chk1 by the ATR (ataxia telangiectasia-mutated and rad3-related) checkpoint kinase.Semantic proximity Read ↗

An essential function for the ATR-activation-domain (AAD) of TopBP1 in mouse development and cellular senescence.Semantic proximity Read ↗

Claspin recruits Cdc7 kinase for initiation of DNA replication in human cellsSemantic proximity Read ↗

A DNA Damage-Regulated BRCT-Containing Protein, TopBP1, Is Required for Cell SurvivalSemantic proximity Read ↗

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