Article
Fitness costs of synonymous mutations in the rpsT gene can be compensated by restoring mRNA base pairing.
PloS one - 1 Jan 2013
Lind Peter A, Andersson Dan I
Abstract excerpt
We previously reported that the distribution of fitness effects for non-synonymous and synonymous mutations in Salmonella typhimurium ribosomal proteins S20 and L1 are similar, suggesting that fitness constraints are present at the level of mRNA. Here we explore the hypothesis that synonymous mutations confer their fitness-reducing effect by alterating the secondary structure of the mRNA. To this end, we...
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