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Article

Fitness benefits of a synonymous substitution in an ancient EF-Tu gene depend on the genetic background.

Journal of bacteriology - 22 Feb 2024

McGrath Kaitlyn M, Russell Steven J, Fer Evrim, Garmendia Eva, Hosgel Ali, Baltrus David A, Kaçar Betül

Abstract excerpt

Synonymous mutations are changes to DNA sequence, which occur within translated genes but which do not affect the protein sequence. Although often referred to as silent mutations, evidence suggests that synonymous mutations can affect gene expression, mRNA stability, and even translation efficiency. A collection of both experimental and bioinformatic data has shown that synonymous mutations can impact cell...

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Identifiers

PMID: 38289064
DOI: 10.1128/jb.00329-23
PMCID: PMC10882980

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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