Synonymous nucleotide divergence and saturation: effects of site-specific variations in codon bias and mutation rates.

Abstract excerpt

The synonymous divergence between Escherichia coli and Salmonella typhimurium is explained in a model where there is a large variation between mutation rates at different nucleotide sites in the genome. The model is based on the experimental observation that spontaneous mutation rates can vary over several orders of magnitude at different sites in a gene. Such site-specific variation must be taken into account...

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