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Article

Effects of mutagenesis of a conserved base-paired site near the decoding region of Escherichia coli 16 S ribosomal RNA.

Journal of molecular biology - 5 Mar 1990

De Stasio E A, Dahlberg A E

Abstract excerpt

Eleven of 15 possible single and double mutations were constructed in a cloned copy of Escherichia coli 16 S rDNA at a base-paired site, 1409-1491. Expression of any of these mutations was detrimental to the growth of E. coli. Mutations that substituted unpaired purine bases were lethal in the system described. Otherwise, the degree of detrimental effect on growth-rate was not directly correlated with specific...

Topics

Anti-Bacterial Agents
Base Composition
Base Sequence
DNA, Bacterial
DNA, Ribosomal
Drug Resistance, Microbial
Escherichia coli
Molecular Sequence Data
Mutation
Nucleic Acid Conformation
Paromomycin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

RNA, Bacterial

RNA, Ribosomal

RNA, Ribosomal, 16S

Source

Identifiers

PMID: 1690811
DOI: 10.1016/0022-2836(90)90309-A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1690811-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Effects of mutagenesis of a conserved base-paired site near the decoding region of Escherichia coli 16 S ribosomal RNA.PMID 1690811Read ↗

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