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Article

Crossing fitness valleys via double substitutions within codons.

BMC biology - 16 Dec 2019

Belinky Frida, Sela Itamar, Rogozin Igor B, Koonin Eugene V

Abstract excerpt

BACKGROUND: Single nucleotide substitutions in protein-coding genes can be divided into synonymous (S), with little fitness effect, and non-synonymous (N) ones that alter amino acids and thus generally have a greater effect. Most of the N substitutions are affected by purifying selection that eliminates them from evolving populations. However, additional mutations of nearby bases potentially could alleviate the...

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Identifiers

PMID: 31842858
DOI: 10.1186/s12915-019-0727-4
PMCID: PMC6916188

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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