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Article

Compensatory evolution reveals functional interactions between ribosomal proteins S12, L14 and L19.

Journal of molecular biology - 9 Feb 2007

Maisnier-Patin Sophie, Paulander Wilhelm, Pennhag Alexandra, Andersson Dan I

Abstract excerpt

Certain mutations in S12, a ribosomal protein involved in translation elongation rate and translation accuracy, confer resistance to the aminoglycoside streptomycin. Previously we showed in Salmonella typhimurium that the fitness cost, i.e. reduced growth rate, due to the amino acid substitution K42N in S12 could be compensated by at least 35 different mutations located in the ribosomal proteins S4, S5 and L19....

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Share to Amino Acid Substitution
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Structure, Tertiary

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Source

Identifiers

PMID: 17157877
DOI: 10.1016/j.jmb.2006.11.047

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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