Article
Mutational robustness of ribosomal protein genes.
Science (New York, N.Y.) - 5 Nov 2010
Lind Peter A, Berg Otto G, Andersson Dan I
Abstract excerpt
The distribution of fitness effects (DFE) of mutations is of fundamental importance for understanding evolutionary dynamics and complex diseases and for conserving threatened species. DFEs estimated from DNA sequences have rarely been subject to direct experimental tests. We used a bacterial system in which the fitness effects of a large number of defined single mutations in two ribosomal proteins were measured...
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