Article
Selection shapes the robustness of ligand-binding amino acids.
Journal of molecular evolution - 1 May 2013
Bilgin Tugce, Kurnaz Isil Aksan, Wagner Andreas
Abstract excerpt
The phenotypes of biological systems are to some extent robust to genotypic changes. Such robustness exists on multiple levels of biological organization. We analyzed this robustness for two categories of amino acids in proteins. Specifically, we studied the codons of amino acids that bind or do not bind small molecular ligands. We asked to what extent codon changes caused by mutation or mistranslation may affect...
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