Article
Perspective: Evolution and detection of genetic robustness.
Evolution; international journal of organic evolution - 1 Sept 2003
de Visser J Arjan G M, Hermisson Joachim, Wagner Günter P, Ancel Meyers Lauren, Bagheri-Chaichian Homayoun, Blanchard Jeffrey L, Chao Lin, Cheverud James M, Elena Santiago F, Fontana Walter, Gibson Greg, Hansen Thomas F, Krakauer David, Lewontin Richard C, Ofria Charles, Rice Sean H, von Dassow George, Wagner Andreas, Whitlock Michael C
Abstract excerpt
Robustness is the invariance of phenotypes in the face of perturbation. The robustness of phenotypes appears at various levels of biological organization, including gene expression, protein folding, metabolic flux, physiological homeostasis, development, and even organismal fitness. The mechanisms underlying robustness are diverse, ranging from thermodynamic stability at the RNA and protein level to behavior at...
Topics
- Adaptation, Biological
- Biological Evolution
- Environment
- Epistasis, Genetic
- Mutation
- Phenotype
- Population Density
- Reproduction
- Selection, Genetic