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Article

Quantifying the Mutational Robustness of Protein-Coding Genes.

Journal of molecular evolution - 1 Jul 2021

Ferrada Evandro

Abstract excerpt

We use large-scale mutagenesis data and computer simulations to quantify the mutational robustness of protein-coding genes by taking into account constraints arising from protein function and the genetic code. Analyses of the distribution of amino acid substitutions from 18 mutagenesis studies revealed an average of 45% of neutral variants; while mutagenesis data of 12 proteins artificially designed under no...

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PMID: 33934169
DOI: 10.1007/s00239-021-10009-1

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