Article
Probability of change in life: Amino acid changes in single nucleotide substitutions.
Bio Systems - 1 Jun 2020
Chan Kwok-Fong, Koukouravas Stelios, Yeo Joshua Yi, Koh Darius Wen-Shuo, Gan Samuel Ken-En
Abstract excerpt
Mutations underpin the processes in life, be it beneficial or detrimental. While mutations are assumed to be random in the bereft of selection pressures, the genetic code has underlying computable probabilities in amino acid phenotypic changes. With a wide range of implications including drug resistance, understanding amino acid changes is important. In this study, we calculated the probabilities of substitutions...
Topics
- Amino Acids
- Genetic Code
- Humans
- Polymorphism, Single Nucleotide
- Probability