Article
Phenotypic characterization of C57BL/6J mice carrying the Disc1 gene from the 129S6/SvEv strain.
Brain structure & function - 1 Jul 2014
Juan Liang-Wen, Liao Chun-Chieh, Lai Wen-Sung, Chang Chia-Yuan, Pei Ju-Chun, Wong Wan-Rong, Liu Chih-Min, Hwu Hai-Gwo, Lee Li-Jen
Abstract excerpt
Disruption of disrupted-in-schizophrenia 1 (DISC1), a candidate susceptibility gene for schizophrenia, was first identified in a large Scottish family in which many members suffered from various psychiatric disorders, including schizophrenia. To model the Scottish DISC1 truncation, we established a Disc1 mutant mouse line in which the 129S6/SvEv 25-bp deletion variant was transferred into the C57BL/6J strain by...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
