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Article

Disc1 is mutated in the 129S6/SvEv strain and modulates working memory in mice.

Proceedings of the National Academy of Sciences of the United States of America - 7 Mar 2006

Koike Hiroko, Arguello P Alexander, Kvajo Mirna, Karayiorgou Maria, Gogos Joseph A

Abstract excerpt

Disrupted-In-Schizophrenia (DISC1) is a leading candidate schizophrenia susceptibility gene. Here, we describe a deletion variant in mDisc1 specific to the 129S6/SvEv strain that introduces a termination codon at exon 7, abolishes production of the full-length protein, and impairs working memory performance when transferred to the C57BL/6J genetic background. Our findings provide insights into how DISC1 variation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16484369
DOI: 10.1073/pnas.0511189103
PMCID: PMC1450143

Genes

DISC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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