Behavioral alterations associated with targeted disruption of exons 2 and 3 of the Disc1 gene in the mouse.

doi:10.1093/hmg/ddr400

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Article

Behavioral alterations associated with targeted disruption of exons 2 and 3 of the Disc1 gene in the mouse.

Human molecular genetics - 1 Dec 2011

Kuroda Keisuke, Yamada Shinnosuke, Tanaka Motoki, Iizuka Michiro, Yano Hisashi, Mori Daisuke, Tsuboi Daisuke, Nishioka Tomoki, Namba Takashi, Iizuka Yukihiko, Kubota Shimpei, Nagai Taku, Ibi Daisuke, Wang Rui, Enomoto Atsushi, Isotani-Sakakibara Mayu, Asai Naoya, Kimura Kazushi, Kiyonari Hiroshi, Abe Takaya, Mizoguchi Akira, Sokabe Masahiro, Takahashi Masahide, Yamada Kiyofumi, Kaibuchi Kozo

Abstract excerpt

Disrupted-In-Schizophrenia 1 (DISC1) is a promising candidate gene for susceptibility to psychiatric disorders, including schizophrenia. DISC1 appears to be involved in neurogenesis, neuronal migration, axon/dendrite formation and synapse formation; during these processes, DISC1 acts as a scaffold protein by interacting with various partners. However, the lack of Disc1 knockout mice and a well-characterized...

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Identifiers

PMID: 21903668
DOI: 10.1093/hmg/ddr400

Genes

DISC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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