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Article

The neuroimaging signature of frontotemporal lobar degeneration associated with Granulin mutations: an effective connectivity study.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine - 1 Jul 2013

Premi Enrico, Grassi Mario, Gazzina Stefano, Paghera Barbara, Pepe Daniele, Archetti Silvana, Padovani Alessandro, Borroni Barbara

Abstract excerpt

UNLABELLED: It has been suggested that monogenic frontotemporal lobar degeneration (FTLD) due to Granulin (GRN) mutations might present a specific pattern of atrophy, as compared with FTLD GRN-negative disease. Recent literature has suggested that the study of functional neural networks, rather than regional structural damage, might better elucidate the pathogenic mechanisms, showing complex relationships among...

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Identifiers

PMID: 23687363
DOI: 10.2967/jnumed.112.111773

Genes

GRN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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