Article
Structural brain splitting is a hallmark of Granulin-related frontotemporal dementia.
Neurobiology of aging - 1 Jun 2022
Gazzina Stefano, Grassi Mario, Premi Enrico, Alberici Antonella, Benussi Alberto, Archetti Silvana, Gasparotti Roberto, Bocchetta Martina, Cash David M, Todd Emily G, Peakman Georgia, Convery Rhian S, van Swieten John C, Jiskoot Lize C, Seelaar Harro, Sanchez-Valle Raquel, Moreno Fermin, Laforce Robert, Graff Caroline, Synofzik Matthis, Galimberti Daniela, Rowe James B, Masellis Mario, Tartaglia Maria Carmela, Finger Elizabeth, Vandenberghe Rik, de Mendonça Alexandre, Tagliavini Fabrizio, Butler Chris R, Santana Isabel, Gerhard Alexander, Ber Isabelle Le, Pasquier Florence, Ducharme Simon, Levin Johannes, Danek Adrian, Sorbi Sandro, Otto Markus, Rohrer Jonathan D, Borroni Barbara
Abstract excerpt
Frontotemporal dementia associated with granulin (GRN) mutations presents asymmetric brain atrophy. We applied a Minimum Spanning Tree plus an Efficiency Cost Optimization approach to cortical thickness data in order to test whether graph theory measures could identify global or local impairment of connectivity in the presymptomatic phase of pathology, where other techniques failed in demonstrating changes. We...
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