Dissemination in time and space in presymptomatic granulin mutation carriers: a GENFI spatial chronnectome study.

doi:10.1016/j.neurobiolaging.2021.09.001

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Article

Dissemination in time and space in presymptomatic granulin mutation carriers: a GENFI spatial chronnectome study.

Neurobiology of aging - 1 Dec 2021

Premi Enrico, Giunta Marcello, Iraji Armin, Rachakonda Srinivas, Calhoun Vince D, Gazzina Stefano, Benussi Alberto, Gasparotti Roberto, Archetti Silvana, Bocchetta Martina, Cash Dave, Todd Emily, Peakman Georgia, Convery Rhian, van Swieten John C, Jiskoot Lize, Sanchez-Valle Raquel, Moreno Fermin, Laforce Robert, Graff Caroline, Synofzik Matthis, Galimberti Daniela, Rowe James B, Masellis Mario, Tartaglia Carmela, Finger Elizabeth, Vandenberghe Rik, de Mendonça Alexandre, Tagliavini Fabrizio, Butler Chris R, Santana Isabel, Gerhard Alexander, Le Ber Isabelle, Pasquier Florence, Ducharme Simon, Levin Johannes, Danek Adrian, Sorbi Sandro, Otto Markus, Rohrer Jonathan D, Borroni Barbara

Abstract excerpt

The presymptomatic brain changes of granulin (GRN) disease, preceding by years frontotemporal dementia, has not been fully characterized. New approaches focus on the spatial chronnectome can capture both spatial network configurations and their dynamic changes over time. To investigate the spatial dynamics in 141 presymptomatic GRN mutation carriers and 282 noncarriers from the Genetic Frontotemporal dementia...

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PMID: 34607248
DOI: 10.1016/j.neurobiolaging.2021.09.001

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