Article
White matter hyperintensities characterize monogenic frontotemporal dementia with granulin mutations.
Neurobiology of aging - 1 Feb 2016
Paternicò Donata, Premi Enrico, Gazzina Stefano, Cosseddu Maura, Alberici Antonella, Archetti Silvana, Cotelli Maria S, Micheli Anna, Turla Marinella, Gasparotti Roberto, Padovani Alessandro, Borroni Barbara
Abstract excerpt
No study but one has suggested the presence of white matter hyperintensities (WMHs) in frontotemporal dementia (FTD), limited to 4 cases carrying pathogenic Granulin (GRN) gene mutations. We investigated the presence of WMHs in a cohort of 14 FTD patients with pathogenic GRN mutations (GRN+), 28 patients without GRN mutations (GRN-) and 18 healthy controls (HC). We further considered 11 asymptomatic GRN+ subjects...
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