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Article

Visualizing group II intron catalysis through the stages of splicing.

Cell - 26 Oct 2012

Marcia Marco, Pyle Anna Marie

Abstract excerpt

Group II introns are self-splicing ribozymes that share a reaction mechanism and a common ancestor with the eukaryotic spliceosome, thereby providing a model system for understanding the chemistry of pre-mRNA splicing. Here we report 14 crystal structures of a group II intron at different stages of catalysis. We provide a detailed mechanism for the first step of splicing, we describe a reversible conformational...

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Identifiers

PMID: 23101623
DOI: 10.1016/j.cell.2012.09.033
PMCID: PMC3628766

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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