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Article

Spliceosome discards intermediates via the DEAH box ATPase Prp43p.

Proceedings of the National Academy of Sciences of the United States of America - 1 Jun 2010

Mayas Rabiah M, Maita Hiroshi, Semlow Daniel R, Staley Jonathan P

Abstract excerpt

To promote fidelity in nuclear pre-mRNA splicing, the spliceosome rejects and discards suboptimal substrates that have engaged the spliceosome. Whereas DExD/H box ATPases have been implicated in rejecting suboptimal substrates, the mechanism for discarding suboptimal substrates has remained obscure. Corroborating evidence that suboptimal, mutated lariat intermediates can be exported to the cytoplasm for turnover,...

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Identifiers

PMID: 20463285
DOI: 10.1073/pnas.0906022107
PMCID: PMC2890470

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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Spliceosome discards intermediates via the DEAH box ATPase Prp43p.PMID 20463285Read ↗

Prp43p is a DEAH-box spliceosome disassembly factor essential for ribosome biogenesis.Semantic proximity Read ↗

Prp43 is an essential RNA-dependent ATPase required for release of lariat-intron from the spliceosome.Semantic proximity Read ↗

RNA repair using spliceosome-mediated RNA trans-splicing.Semantic proximity Read ↗

The DExD/H-box ATPase Prp2p destabilizes and proofreads the catalytic RNA core of the spliceosome.Semantic proximity Read ↗

Structural toggle in the RNaseH domain of Prp8 helps balance splicing fidelity and catalytic efficiency.Semantic proximity Read ↗

"Nought may endure but mutability": spliceosome dynamics and the regulation of splicing.Semantic proximity Read ↗

The debranching enzyme Dbr1 regulates lariat turnover and intron splicingSemantic proximity Read ↗

Pathogenic proteotoxicity of cryptic splicing is alleviated by ubiquitination and ER-phagySemantic proximity Read ↗

A mechanism to enhance mRNA splicing fidelity: the RNA-dependent ATPase Prp16 governs usage of a discard pathway for aberrant lariat intermediates.Semantic proximity Read ↗

Activation of Prp28 ATPase by phosphorylated Npl3 at a critical step of spliceosome remodeling.Semantic proximity Read ↗

Direct and indirect effects of spliceosome disruption compromise gene regulation by Nonsense-Mediated mRNA DecaySemantic proximity Read ↗

Competition between the ATPase Prp5 and branch region-U2 snRNA pairing modulates the fidelity of spliceosome assembly.Semantic proximity Read ↗

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