Article
Sensitivity of the Pig-a assay for detecting gene mutation in rats exposed acutely to strong clastogens.
Mutagenesis - 1 Jul 2013
Bhalli Javed A, Shaddock Joseph G, Pearce Mason G, Dobrovolsky Vasily N
Abstract excerpt
Clastogens are potential human carcinogens whose detection by genotoxicity assays is important for safety assessment. Although some endogenous genes are sensitive to the mutagenicity of clastogens, many genes that are used as reporters for in vivo mutation (e.g. transgenes) are not. In this study, we have compared responses in the erythrocyte Pig-a gene mutation assay with responses in a gene mutation assay that...
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