Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rat Pig-a mutation assay responds to the genotoxic carcinogen ethyl carbamate but not the non-genotoxic carcinogen methyl carbamate.

Mutagenesis - 1 May 2015

Bemis Jeffrey C, Labash Carson, Avlasevich Svetlana L, Carlson Kristine, Berg Ariel, Torous Dorothea K, Barragato Matthew, MacGregor James T, Dertinger Stephen D

Abstract excerpt

Determination of the mode of action of carcinogenic agents is an important factor in risk assessment and regulatory practice. To assess the ability of the erythrocyte-based Pig-a mutation assay to discriminate between genotoxic and non-genotoxic modes of action, the mutagenic response of Sprague Dawley rats exposed to methyl carbamate (MC) or ethyl carbamate (EC) was investigated. EC, a potent carcinogen, is...

Topics

Animals
Carbamates
Carcinogens
DNA Damage
Male
Membrane Proteins
Micronucleus Tests
Mutagenesis
Mutagens
Mutation
Rats, Sprague-Dawley

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Reticulocytes

Urethane

Source

Open in PubMed Open full text

Identifiers

PMID: 25833916
DOI: 10.1093/mutage/geu084
PMCID: PMC4422867

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-25833916-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rat Pig-a mutation assay responds to the genotoxic carcinogen ethyl carbamate but not the non-genotoxic carcinogen methyl carbamate.PMID 25833916Read ↗

Mouse Pig-a and micronucleus assays respond to N-ethyl-N-nitrosourea, benzo[a]pyrene, and ethyl carbamate, but not pyrene or methyl carbamate.Semantic proximity Read ↗

The PIGRET assay, a method for measuring Pig-a gene mutation in reticulocytes, is reliable as a short-term in vivo genotoxicity test: Summary of the MMS/JEMS-collaborative study across 16 laboratories using 24 chemicals.Semantic proximity Read ↗

Pig-a gene mutation and micronucleated reticulocyte induction in rats exposed to tumorigenic doses of the leukemogenic agents chlorambucil, thiotepa, melphalan, and 1,3-propane sultone.Semantic proximity Read ↗

Sensitivity of the Pig-a assay for detecting gene mutation in rats exposed acutely to strong clastogens.Semantic proximity Read ↗

Efficient monitoring of in vivo pig-a gene mutation and chromosomal damage: summary of 7 published studies and results from 11 new reference compounds.Semantic proximity Read ↗

Induction of Pig-a mutant erythrocytes in male and female rats exposed to 1,3-propane sultone, ethyl carbamate, or thiotepa.Semantic proximity Read ↗

Continued progress in developing the Pig-a gene mutation assay.Semantic proximity Read ↗

Compensatory erythropoiesis has no impact on the outcome of the in vivo Pig-a mutation assay in rats following treatment with the haemolytic agent 2-butoxyethanol.Semantic proximity Read ↗

Detection of Pig-a gene mutants in rat peripheral blood following a single urethane treatment: A comparison of the RBC Pig-a and PIGRET assays.Semantic proximity Read ↗

In vivo flow cytometric Pig-a and micronucleus assays: highly sensitive discrimination of the carcinogen/noncarcinogen pair benzo(a)pyrene and pyrene using acute and repeated-dose designs.Semantic proximity Read ↗

The Pig-a Gene Mutation Assay in Mice and Human Cells: A Review.Semantic proximity Read ↗

[Genotoxicity assessment of 2-ethylhexyl acrylate using an in vivo Pig-a gene mutation assay integrated system].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.