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Article

Rat Pig-a mutation assay responds to the genotoxic carcinogen ethyl carbamate but not the non-genotoxic carcinogen methyl carbamate.

Mutagenesis - 1 May 2015

Bemis Jeffrey C, Labash Carson, Avlasevich Svetlana L, Carlson Kristine, Berg Ariel, Torous Dorothea K, Barragato Matthew, MacGregor James T, Dertinger Stephen D

Abstract excerpt

Determination of the mode of action of carcinogenic agents is an important factor in risk assessment and regulatory practice. To assess the ability of the erythrocyte-based Pig-a mutation assay to discriminate between genotoxic and non-genotoxic modes of action, the mutagenic response of Sprague Dawley rats exposed to methyl carbamate (MC) or ethyl carbamate (EC) was investigated. EC, a potent carcinogen, is...

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Identifiers

PMID: 25833916
DOI: 10.1093/mutage/geu084
PMCID: PMC4422867

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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