Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutant presenilin 1 expression in excitatory neurons impairs enrichment-mediated phenotypes of adult hippocampal progenitor cells.

Proceedings of the National Academy of Sciences of the United States of America - 28 May 2013

Veeraraghavalu Karthikeyan, Sisodia Sangram S

Abstract excerpt

Inheritance of mutant presenilin 1 genes (PSEN1) encoding presenilin 1 (PS1)variants causes autosomal dominant forms of familial Alzheimer's disease (FAD). We previously reported that ubiquitous expression of FAD-linked PS1 variants in mice impairs environmental enrichment (EE)-induced proliferation and neuronal commitment of adult hippocampal neural progenitor cells (AHNPCs). Notably, the self-renewal and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bromodeoxyuridine
Share to Cell Survival

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hippocampus

Share to Presenilin-1

Share to Prosencephalon

Share to Stem Cells

Share to Tamoxifen

Share to Transgenes

Source

Open in PubMed Open full text

Identifiers

PMID: 23674689
DOI: 10.1073/pnas.1302106110
PMCID: PMC3670351

Genes

PSEN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutant presenilin 1 expression in excitatory neurons impairs enrichment-mediated phenotypes of adult hippocampal progenitor cells.PMID 23674689Read ↗

The presenilin-1 familial Alzheimer disease mutant P117L impairs neurogenesis in the hippocampus of adult mice.Semantic proximity Read ↗

Presenilin 1 mutants impair the self-renewal and differentiation of adult murine subventricular zone-neuronal progenitors via cell-autonomous mechanisms involving notch signaling.Semantic proximity Read ↗

Expression of familial Alzheimer's disease-linked human presenilin 1 variants impair enrichment-induced adult hippocampal neurogenesis.Semantic proximity Read ↗

Overexpression of wild type but not an FAD mutant presenilin-1 promotes neurogenesis in the hippocampus of adult mice.Semantic proximity Read ↗

Familial Alzheimer's Disease Mutations in PSEN1 Lead to Premature Human Stem Cell Neurogenesis.Semantic proximity Read ↗

Induced Pluripotent Stem Cells from Familial Alzheimer's Disease Patients Differentiate into Mature Neurons with Amyloidogenic PropertiesSemantic proximity Read ↗

Characterization and molecular profiling of PSEN1 familial Alzheimer's disease iPSC-derived neural progenitors.Semantic proximity Read ↗

Characterization of adult hippocampal neurogenesis in the novel <i> App <sup>SAA</sup> </i> Knock-in Alzheimer’s disease mouse modelSemantic proximity Read ↗

Alzheimer’s Disease Mutations Disrupt Neural Stem Cell Fate and Early Brain DevelopmentSemantic proximity Read ↗

The presenilin-1 familial Alzheimer's disease mutation P117L decreases neuronal differentiation of embryonic murine neural progenitor cells.Semantic proximity Read ↗

The presenilin-1 ΔE9 mutation results in reduced γ-secretase activity, but not total loss of PS1 function, in isogenic human stem cells.Semantic proximity Read ↗

Impaired neurogenesis is an early event in the etiology of familial Alzheimer's disease in transgenic mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.