Article
The presenilin-1 familial Alzheimer disease mutant P117L impairs neurogenesis in the hippocampus of adult mice.
Experimental neurology - 1 Aug 2004
Wen Paul H, Hof Patrick R, Chen Xiaoping, Gluck Karen, Austin Gregory, Younkin Steven G, Younkin Linda H, DeGasperi Rita, Gama Sosa Miguel A, Robakis Nikolaos K, Haroutunian Vahram, Elder Gregory A
Abstract excerpt
The functions of presenilin 1 (PS1) and how PS1 mutations cause familial Alzheimer's disease (FAD) are incompletely understood. PS1 expression is essential for neurogenesis during embryonic development and may also influence neurogenesis in adult brain. We examined how increasing PS1 expression or expressing an FAD mutant would affect neurogenesis in the adult hippocampus. A neuron-specific enolase (NSE) promoter...
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