Article
The presenilin-1 familial Alzheimer's disease mutation P117L decreases neuronal differentiation of embryonic murine neural progenitor cells.
Brain research bulletin - 28 Oct 2009
Eder-Colli Lorenza, Abad-Estarlich Noelia, Pannetier Carine, Vallet Philippe G, Walzer Claude, Elder Gregory A, Robakis Nikolaos K, Bouras Constantin, Savioz Armand
Abstract excerpt
The presenilin-1 gene is mutated in early-onset familial Alzheimer's disease. The mutation Pro117Leu is implicated in a very severe form of the disease, with an onset of less than 30 years. The consequences of this mutation on neurogenesis in the hippocampus of adult transgenic mice have already been studied in situ. The survival of neural progenitor cells was impaired resulting in decreased neurogenesis in the...
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