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Article

Expression of familial Alzheimer's disease-linked human presenilin 1 variants impair enrichment-induced adult hippocampal neurogenesis.

Neuro-degenerative diseases - 1 Jan 2010

Veeraraghavalu Karthikeyan, Choi Se Hoon, Sisodia Sangram S

Abstract excerpt

Presenilin 1 (PS1) plays a critical role in neurogenesis both during development and in the adult. We recently reported that ubiquitous expression of familial, early-onset Alzheimer's disease-linked PS1 mutants impairs enrichment-induced proliferation and neurogenesis of hippocampal neural progen...

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PMID: 20160458
DOI: 10.1159/000283482

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20160458-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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