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Article

Role of a polymorphism in a Hox/Pax-responsive enhancer in the evolution of the vertebrate spine.

Proceedings of the National Academy of Sciences of the United States of America - 25 Jun 2013

Guerreiro Isabel, Nunes Andreia, Woltering Joost M, Casaca Ana, Nóvoa Ana, Vinagre Tânia, Hunter Margaret E, Duboule Denis, Mallo Moisés

Abstract excerpt

Patterning of the vertebrate skeleton requires the coordinated activity of Hox genes. In particular, Hox10 proteins are essential to set the transition from thoracic to lumbar vertebrae because of their rib-repressing activity. In snakes, however, the thoracic region extends well into Hox10-expre...

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Share to Body Patterning
Share to Conserved Sequence
Share to Enhancer Elements, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Homeobox

Share to Myogenic Regulatory Factor 5

Share to Paired Box Transcription Factors

Share to Sequence Homology, Nucleic Acid

Source

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Identifiers

PMID: 23674686
DOI: 10.1073/pnas.1300592110
PMCID: PMC3696775

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23674686-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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