Article
Functional specificity of Hoxa-4 in vertebral patterning lies outside of the homeodomain.
Proceedings of the National Academy of Sciences of the United States of America - 3 Sept 1996
Sreenath T L, Pollock R A, Bieberich C J
Abstract excerpt
The Hox family of proteins plays a central role in establishing the body plan of a wide range of metazoan organisms. Each member of this family of transcriptional regulators has a distinct functional specificity, yet they bind to similar DNA target sequences through their conserved homeodomain. The mechanisms whereby Hox proteins achieve their diverse specificities in vivo remain undefined. Using the opposing...
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