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Article

Regulatory role for a conserved motif adjacent to the homeodomain of Hox10 proteins.

Development (Cambridge, England) - 1 Aug 2012

Guerreiro Isabel, Casaca Ana, Nunes Andreia, Monteiro Sara, Nóvoa Ana, Ferreira Ricardo B, Bom Joana, Mallo Moisés

Abstract excerpt

Development of the vertebrate axial skeleton requires the concerted activity of several Hox genes. Among them, Hox genes belonging to the paralog group 10 are essential for the formation of the lumbar region of the vertebral column, owing to their capacity to block rib formation. In this work, we explored the basis for the rib-repressing activity of Hox10 proteins. Because genetic experiments in mice demonstrated...

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Identifiers

PMID: 22721778
DOI: 10.1242/dev.081448

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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