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Article

Regulatory divergence modifies limb length between mammals.

Genes & development - 15 Jan 2008

Cretekos Chris J, Wang Ying, Green Eric D, Martin James F, Rasweiler John J, Behringer Richard R

Abstract excerpt

Natural selection acts on variation within populations, resulting in modified organ morphology, physiology, and ultimately the formation of new species. Although variation in orthologous proteins can contribute to these modifications, differences in DNA sequences regulating gene expression may be a primary source of variation. We replaced a limb-specific transcriptional enhancer of the mouse Prx1 locus with the...

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Share to Biological Evolution
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Share to Enhancer Elements, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genes, Homeobox

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Share to Regulatory Sequences, Nucleic Acid

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Identifiers

PMID: 18198333
DOI: 10.1101/gad.1620408
PMCID: PMC2192750

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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