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Article

Progressive Loss of Function in a Limb Enhancer during Snake Evolution.

Cell - 20 Oct 2016

Kvon Evgeny Z, Kamneva Olga K, Melo Uirá S, Barozzi Iros, Osterwalder Marco, Mannion Brandon J, Tissières Virginie, Pickle Catherine S, Plajzer-Frick Ingrid, Lee Elizabeth A, Kato Momoe, Garvin Tyler H, Akiyama Jennifer A, Afzal Veena, Lopez-Rios Javier, Rubin Edward M, Dickel Diane E, Pennacchio Len A, Visel Axel

Abstract excerpt

The evolution of body shape is thought to be tightly coupled to changes in regulatory sequences, but specific molecular events associated with major morphological transitions in vertebrates have remained elusive. We identified snake-specific sequence changes within an otherwise highly conserved long-range limb enhancer of Sonic hedgehog (Shh). Transgenic mouse reporter assays revealed that the in vivo activity...

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Share to Biological Evolution
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27768887
DOI: 10.1016/j.cell.2016.09.028
PMCID: PMC5484524

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