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Article

TALEN-mediated editing of the mouse Y chromosome.

Nature biotechnology - 1 Jun 2013

Wang Haoyi, Hu Yueh-Chiang, Markoulaki Styliani, Welstead G Grant, Cheng Albert W, Shivalila Chikdu S, Pyntikova Tatyana, Dadon Daniel B, Voytas Daniel F, Bogdanove Adam J, Page David C, Jaenisch Rudolf

Abstract excerpt

The functional study of Y chromosome genes has been hindered by a lack of mouse models with specific Y chromosome mutations. We used transcription activator-like effector nuclease (TALEN)-mediated gene editing in mouse embryonic stem cells (mESCs) to produce mice with targeted gene disruptions an...

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Identifiers

PMID: 23666012
DOI: 10.1038/nbt.2595
PMCID: PMC3681814

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23666012-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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