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Article

The mouse <i>Sry</i> locus harbors a cryptic exon that is essential for male sex determination

2 Oct 2020

Abstract excerpt

Two rather than one For several decades, it has been believed that the mammalian sex-determining gene Sry contains a single exon. Miyawaki et al. have now identified a cryptic second exon of mouse Sry . Loss- and gain-of-function analyses revealed that the two-exon SRY (SRY-T), not the canonical single exon–encoded SRY (SRY-S), is the bona fide testis-determining factor. Sry exon2 is composed of...

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PMID: 33004521
DOI: 10.1126/science.abb6430

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