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Article

Comment on "Evidence of abundant purifying selection in humans for recently acquired regulatory functions".

Science (New York, N.Y.) - 10 May 2013

Green Phil, Ewing Brent

Abstract excerpt

Ward and Kellis (Reports, 28 September 2012, p. 1675; published online 5 September 2012) found altered patterns of human polymorphism in biochemically active but non-mammalian-conserved genomic regions relative to control regions and interpreted this as due to lineage-specific purifying selection. We find on closer inspection of their data that the polymorphism trends are primarily attributable to mutational...

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Share to Gene Expression Regulation
Share to Genetic Variation
Share to Genome, Human

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Regulatory Sequences, Nucleic Acid

Share to Selection, Genetic

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Identifiers

PMID: 23661742
DOI: 10.1126/science.1233195

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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