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Article

Human variation in short regions predisposed to deep evolutionary conservation.

Molecular biology and evolution - 1 Jun 2010

Loots Gabriela G, Ovcharenko Ivan

Abstract excerpt

The landscape of the human genome consists of millions of short islands of conservation that are 100% conserved across multiple vertebrate genomes (termed "bricks"), the majority of which are located in noncoding regions. Several hundred thousand bricks are deeply conserved reaching the genomes of amphibians and fish. Deep phylogenetic conservation of noncoding DNA has been reported to be strongly associated with...

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Identifiers

PMID: 20093432
DOI: 10.1093/molbev/msq011
PMCID: PMC2872621

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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