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Article

Novelty versus innovation of gene regulatory elements in human evolution and disease.

Current opinion in genetics & development - 1 Feb 2025

Katikaneni Anushka, Lowe Craig B

Abstract excerpt

It is not currently understood how much of human evolution is due to modifying existing functional elements in the genome versus forging novel elements from nonfunctional DNA. Many early experiments that aimed to assign genetic changes on the human lineage to their resulting phenotypic change have focused on mutations that modify existing elements. However, a number of recent studies have highlighted the...

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Identifiers

PMID: 39591813
DOI: 10.1016/j.gde.2024.102279
PMCID: PMC11769741

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