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Article

Inferring Selective Constraint from Population Genomic Data Suggests Recent Regulatory Turnover in the Human Brain.

Genome biology and evolution - 19 Nov 2015

Schrider Daniel R, Kern Andrew D

Abstract excerpt

The comparative genomics revolution of the past decade has enabled the discovery of functional elements in the human genome via sequence comparison. While that is so, an important class of elements, those specific to humans, is entirely missed by searching for sequence conservation across species. Here we present an analysis based on variation data among human genomes that utilizes a supervised machine learning...

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Share to Brain
Share to Evolution, Molecular
Share to Genome, Human

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polymorphism, Single Nucleotide

Share to Receptors, Neurotransmitter

Share to Regulatory Sequences, Nucleic Acid

Share to Selection, Genetic

Source

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Identifiers

PMID: 26590212
DOI: 10.1093/gbe/evv228
PMCID: PMC4700959

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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