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Article

Response to comment on "Evidence of abundant purifying selection in humans for recently acquired regulatory functions".

Science (New York, N.Y.) - 10 May 2013

Ward Lucas D, Kellis Manolis

Abstract excerpt

Green and Ewing propose corrections to our methodology, which we incorporate and extend here. The improved methodology supports our initial conclusion of extensive lineage-specific constraint concentrated in ENCODE elements. We clarify that our estimate is dependent on the constrained and neutral references used, which can further increase the number of nucleotides involved, because a particularly stringent...

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Share to Gene Expression Regulation
Share to Genetic Variation
Share to Genome, Human

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Regulatory Sequences, Nucleic Acid

Share to Selection, Genetic

Source

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Identifiers

PMID: 23661743
DOI: 10.1126/science.1233366
PMCID: PMC4131756

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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