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Article

Evaluating power and type 1 error in large pedigree analyses of binary traits.

PloS one - 1 Jan 2013

Cummings Anna C, Torstenson Eric, Davis Mary F, D'Aoust Laura N, Scott William K, Pericak-Vance Margaret A, Bush William S, Haines Jonathan L

Abstract excerpt

Studying population isolates with large, complex pedigrees has many advantages for discovering genetic susceptibility loci; however, statistical analyses can be computationally challenging. Allelic association tests need to be corrected for relatedness among study participants, and linkage analys...

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Identifiers

PMID: 23658753
DOI: 10.1371/journal.pone.0062615
PMCID: PMC3643945

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23658753-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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