Obtaining accurate p values from a dense SNP linkage scan.

doi:10.1159/000342754

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Article

Obtaining accurate p values from a dense SNP linkage scan.

Human heredity - 1 Jan 2012

Stewart William C L, Subaran Ryan L

Abstract excerpt

A major concern of resequencing studies is that the pathogenicity of most mutations is difficult to predict. To address this concern, linkage (i.e. co-segregation) analysis is often used to exclude neutral mutations and to better predict pathogenicity among the candidate mutations that remain. Ho...

Topics

Genetic Linkage
Genome, Human
Haplotypes
Humans
Linkage Disequilibrium
Polymorphism, Single Nucleotide
Software

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