Article
Obtaining accurate p values from a dense SNP linkage scan.
Human heredity - 1 Jan 2012
Stewart William C L, Subaran Ryan L
Abstract excerpt
A major concern of resequencing studies is that the pathogenicity of most mutations is difficult to predict. To address this concern, linkage (i.e. co-segregation) analysis is often used to exclude neutral mutations and to better predict pathogenicity among the candidate mutations that remain. However, when linkage disequilibrium (LD) is present in the population but ignored in the analysis, unlinked regions with...
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