Article
The role of large pedigrees in an era of high-throughput sequencing.
Human genetics - 1 Oct 2012
Wijsman Ellen M
Abstract excerpt
Rare variation is the current frontier in human genetics. The large pedigree design is practical, efficient, and well-suited for investigating rare variation. In large pedigrees, specific rare variants that co-segregate with a trait will occur in sufficient numbers so that effects can be measured, and evidence for association can be evaluated, by making use of methods that fully use the pedigree information....
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