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Article

A statistical framework to guide sequencing choices in pedigrees.

American journal of human genetics - 6 Feb 2014

Cheung Charles Y K, Marchani Blue Elizabeth, Wijsman Ellen M

Abstract excerpt

The use of large pedigrees is an effective design for identifying rare functional variants affecting heritable traits. Cost-effective studies using sequence data can be achieved via pedigree-based genotype imputation in which some subjects are sequenced and missing genotypes are inferred on the remaining subjects. Because of high cost, it is important to carefully prioritize subjects for sequencing. Here, we...

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Identifiers

PMID: 24507777
DOI: 10.1016/j.ajhg.2014.01.005
PMCID: PMC3928665

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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