Inferring haplotypes and parental genotypes in larger full sib-ships and other pedigrees with missing or erroneous genotype data.

doi:10.1186/1471-2156-13-85

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Article

Inferring haplotypes and parental genotypes in larger full sib-ships and other pedigrees with missing or erroneous genotype data.

BMC genetics - 10 Oct 2012

Nettelblad Carl

Abstract excerpt

BACKGROUND: In many contexts, pedigrees for individuals are known even though not all individuals have been fully genotyped. In one extreme case, the genotypes for a set of full siblings are known, with no knowledge of parental genotypes. We propose a method for inferring phased haplotypes and genotypes for all individuals, even those with missing data, in such pedigrees, allowing a multitude of classic and...

Topics

Genotype
Haplotypes
Humans
Markov Chains
Models, Statistical
Parents
Pedigree
Siblings

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Identifiers

PMID: 23046532
DOI: 10.1186/1471-2156-13-85
PMCID: PMC3562206

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