Article
Comparative study of multipoint methods for genotype error detection.
Human heredity - 1 Jan 2004
Mukhopadhyay Nandita, Buxbaum Sarah G, Weeks Daniel E
Abstract excerpt
Several programs are currently available for the detection of genotyping error that may or may not be Mendelianly inconsistent. However, no systematic study exists that evaluates their performance under varying pedigree structures and sizes, marker spacing, and allele frequencies. Our simulation study compares four multipoint methods: Merlin, Mendel4, SimWalk2, and Sibmed. We look at empirical thresholds, power,...
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