Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

BRAF V600E mutation detection by immunohistochemistry in colorectal carcinoma

7 May 2013

Abstract excerpt

The serine/threonine-protein kinase B-raf (BRAF) is an oncogene mutated in various neoplasms, including 5-15% of colorectal carcinomas. The T1799A point mutation, responsible for a large majority of these alterations, results in an amino acid substitution (V600E) causing the constitutive activation of a protein kinase cascade. BRAF V600E in MLH1 deficient tumors implicates somatic tumor-only methylation of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to Colorectal Cancer Treatments and Studies
Share to Genetic factors in colorectal cancer

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23650027
DOI: 10.1002/gcc.22070

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

BRAF V600E mutation detection by immunohistochemistry in colorectal carcinomaPMID 23650027Read ↗

BRAF mutation testing in colorectal cancer.Semantic proximity Read ↗

Diagnostic value of immunohistochemistry for the detection of the BRAF V600E mutation in colorectal carcinoma.Semantic proximity Read ↗

Immunohistochemical detection of the BRAF V600E mutant protein in colorectal neoplasms.Semantic proximity Read ↗

BRAFV600E Gene Mutation in Colonic Adenocarcinomas. Immunohistochemical Detection Using Tissue Microarray and Clinicopathologic Characteristics: An 86 Case Series.Semantic proximity Read ↗

A molecular signature for oncogenic BRAF in human colon cancer cells is revealed by microarray analysis.Semantic proximity Read ↗

Mutation‐specific antibody detects mutant BRAF<sup>V600E</sup> protein expression in human colon carcinomasSemantic proximity Read ↗

BRAFV600E immunohistochemistry can reliably substitute BRAF molecular testing in the Lynch syndrome screening algorithm in colorectal cancer.Semantic proximity Read ↗

BRAF mutation in sporadic colorectal cancer and Lynch syndrome.Semantic proximity Read ↗

Immunohistochemical Examination is Highly Sensitive and Specific for Detection of the V600E BRAF Mutation in Colorectal Serrated Lesions.Semantic proximity Read ↗

BRAF mutations are associated with distinctive clinical, pathological and molecular features of colorectal cancer independently of microsatellite instability status.Semantic proximity Read ↗

Prevalence and prognostic relevance of BrafV600E mutation in colorectal carcinomas from Kashmir (North India) valley.Semantic proximity Read ↗

Pyrosequencing-based methods reveal marked inter-individual differences in oncogene mutation burden in human colorectal tumours.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.