BRAFV600E Gene Mutation in Colonic Adenocarcinomas. Immunohistochemical Detection Using Tissue Microarray and Clinicopathologic Characteristics: An 86 Case Series.

doi:10.1097/PAI.0000000000000157

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Article

BRAFV600E Gene Mutation in Colonic Adenocarcinomas. Immunohistochemical Detection Using Tissue Microarray and Clinicopathologic Characteristics: An 86 Case Series.

Applied immunohistochemistry & molecular morphology : AIMM - 1 Feb 2016

Boulagnon Camille, Dudez Oriane, Beaudoux Olivia, Dalstein Véronique, Kianmanesh Reza, Bouché Olivier, Diebold Marie-Danièle

Abstract excerpt

The detection of BRAF mutation in colorectal cancer has several clinical applications: enabling the discrimination between sporadic and Lynch syndrome-related colorectal carcinoma, and providing warning of a poorer prognosis. Few immunohistochemical studies using whole-tissue tumor section staining have recently been performed on colorectal cancer. The aim of this study was to evaluate the detection of BRAF...

Topics

Adenocarcinoma
Adult
Aged
Aged, 80 and over
Colonic Neoplasms
Colorectal Neoplasms, Hereditary Nonpolyposis
Diagnosis, Differential
Female
Follow-Up Studies
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunohistochemistry

Male

Middle Aged

Mutation

Neoplasm Staging

Predictive Value of Tests

Prognosis

Proto-Oncogene Proteins B-raf

Source

Open in PubMed

Identifiers

PMID: 25710585
DOI: 10.1097/PAI.0000000000000157

Genes

BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-25710585-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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