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Article

Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism.

Proceedings of the National Academy of Sciences of the United States of America - 9 Feb 2010

Komatsu Mamoru, Uchiyama Takuma, Omura Satoshi, Cane David E, Ikeda Haruo

Abstract excerpt

To construct a versatile model host for heterologous expression of genes encoding secondary metabolite biosynthesis, the genome of the industrial microorganism Streptomyces avermitilis was systematically deleted to remove nonessential genes. A region of more than 1.4 Mb was deleted stepwise from...

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Identifiers

PMID: 20133795
DOI: 10.1073/pnas.0914833107
PMCID: PMC2823899

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20133795-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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