Article
Reverse biological engineering of hrdB to enhance the production of avermectins in an industrial strain of Streptomyces avermitilis.
Proceedings of the National Academy of Sciences of the United States of America - 22 Jun 2010
Zhuo Ying, Zhang Wenquan, Chen Difei, Gao Hong, Tao Jun, Liu Mei, Gou Zhongxuan, Zhou Xianlong, Ye Bang-Ce, Zhang Qing, Zhang Siliang, Zhang Li-Xin
Abstract excerpt
Avermectin and its analogues are produced by the actinomycete Streptomyces avermitilis and are widely used in the field of animal health, agriculture, and human health. Here we have adopted a practical approach to successfully improve avermectin production in an industrial overproducer. Transcriptional levels of the wild-type strain and industrial overproducer in production cultures were monitored using...
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